发明名称 |
BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS |
摘要 |
Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |
申请公布号 |
EA020578(B1) |
申请公布日期 |
2014.12.30 |
申请号 |
EA20110070137 |
申请日期 |
2009.07.02 |
申请人 |
SIRTRIS PHARMACEUTICALS, INC. |
发明人 |
VU CHI, B.;DISCH JEREMY, S.;NG PUI, YEE;BLUM CHARLES, A.;PERNI ROBERT, B. |
分类号 |
C07D401/12;A61K31/4184;A61K31/437;C07D401/14;C07D403/12;C07D403/14;C07D405/12;C07D405/14;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D471/04;C07D471/08;C07D513/04 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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