PROCESSO PARA ISOLAR UM OU MAIS COMPOSTOS ALVO DE UM LÍQUIDO AQUOSO, PROCESSO DE MULTIETAPAS PARA ISOLAR UM OU MAIS COMPOSTOS ALVO, E, MÉTODO PARA ISOLAR PELO MENOS UM ANTICORPO DE UM LÍQUIDO

摘要

The present invention relates to a process of isolating one or more target compounds, wherein the clarification of feed is performed using partitioning in a multiphase system comprising a first polymer, which is a synthetic poly(acid), a second synthetic polymer, which is a poly(ether), and at least one salt, which clarification is followed by at least one step of affinity chromatography. The molecular weight of the poly(acid) may be in the range of 1000-100,000 Da. The target compound is preferably a biomolecule, such as a monoclonal antibody.