发明名称 |
HIGH-TRANSDUCTION-EFFICIENCY RAAV VECTORS, COMPOSITIONS, AND METHODS OF USE |
摘要 |
The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions. |
申请公布号 |
SG11201407529W(A) |
申请公布日期 |
2014.12.30 |
申请号 |
SG11201407529W |
申请日期 |
2013.05.15 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
SRIVASTAVA, ARUN;ASLANIDI, GEORGE VLADIMIROVICH;VAN VLIET, KIM M.;AGBANDJE-MCKENNA, MAVIS |
分类号 |
C07K14/05;A61K38/16;A61K48/00;C12N15/35;C12N15/864 |
主分类号 |
C07K14/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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