| 发明名称 | Methods and materials for the detection of dengue virus infection | ||
| 摘要 | The present invention provides monoclonal antibodies that are specific for the Dengue non-structural glycoprotein NS1 in monomeric and/or oligomeric (primarily dimeric) form, together with methods, including ELISA and lateral flow assays, that employ the disclosed antibodies for the early detection of Dengue virus infection. Diagnostic kits for the detection of Dengue infection are also provided, such kits including the disclosed monoclonal and/or polyclonal antibodies. | ||
| 申请公布号 | US8920804(B2) | 申请公布日期 | 2014.12.30 |
| 申请号 | US201213629445 | 申请日期 | 2012.09.27 |
| 申请人 | InBios International, Inc. | 发明人 | Raychaudhuri Syamal;Houghton Raymond L.;Morkowski Stanislaw;Stevens Yvonne;Bose Mohua;Needham James William;Chen Hongjing |
| 分类号 | A61K39/42;C07K16/08;G01N33/569 | 主分类号 | A61K39/42 |
| 代理机构 | Speckman Law Group PLLC | 代理人 | Sleath Janet;Speckman Law Group PLLC |
| 主权项 | 1. A monoclonal antibody, or antigen binding fragment thereof, that is specific for a dengue virus NS1 polypeptide, wherein the monoclonal antibody comprises a heavy chain variable region comprising SEQ ID NO: 2 and a light chain variable region comprising SEQ ID NO: 3. | ||
| 地址 | Seattle WA US | ||