Myostatin binding agents, nucleic acids encoding the same, and methods of treatment

摘要

The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.

主权项

1. A binding agent capable of binding myostatin comprising the structure F1-(L1)-P1 or multimers thereof, wherein F1 is a human IgG Fc, wherein L1 is (Gly)5, wherein the binding agent further comprises AQ and wherein P1 is SEQ ID NO: 311.