Contrast agents

摘要

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

主权项

1. Compounds of formula (I)
R—N(CHO)—X—N(R3)—R   (I) Formula (I) and salts or optical active isomers thereof, wherein X denotes a C3 to C8 straight or branched alkylene moiety optionally with one or two CH2 moieties replaced by oxygen atoms, sulphur atoms or NR1 groups and wherein the alkylene moiety optionally is substituted by up to six —OR1 groups; R1 denotes a hydrogen or a C1 to C4 straight or branched alkyl group; R3 denotes a formyl moiety; and each R independently is the same or different and denote a triiodinated phenyl group further substituted by two groups R2 wherein each R2 is the same or different and denotes a hydrogen atom or a non-ionic hydrophilic moiety, provided that at least one R2 group in the compound of formula (I) is a hydrophilic moiety.