ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
摘要
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
申请公布号
SG11201407297V(A)
申请公布日期
2014.12.30
申请号
SG11201407297V
申请日期
2013.05.09
申请人
CODEXIS, INC.
发明人
CHEN, HAIBIN;MOORE, JEFFREY;COLLIER, STEVEN J.;SMITH, DEREK;NAZOR, JOVANA;HUGHES, GREGORY;JANEY, JACOB;HUISMAN, GJALT;NOVICK, SCOTT;AGARD, NICHOLAS;ALVIZO, OSCAR;COPE, GREGORY;YEO, WAN LIN;SUKUMARAN, JOLY;MINOR, STEFANIE, NG