| 发明名称 | Sustained-release composition and method for producing the same | ||
| 摘要 | Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same. | ||
| 申请公布号 | US8921326(B2) | 申请公布日期 | 2014.12.30 |
| 申请号 | US200712312751 | 申请日期 | 2007.12.17 |
| 申请人 | Takeda Pharmaceutical Company Limited | 发明人 | Futo Tomomichi;Saito Kazuhiro;Hoshino Tetsuo;Hori Masuhisa |
| 分类号 | A61K38/08;A61K9/19;A61K9/50;A61K31/55;A61K9/00 | 主分类号 | A61K38/08 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Foley & Lardner LLP |
| 主权项 | 1. A sustained-release composition in which a physiologically active substance, which is a peptide of formula:5-oxo-Pro-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NH-C2H5 or an acetate thereof, is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, wherein the physiologically active substance is contained in an amount of 15 to 35 (weight/weight) % to the total microcapsules, weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, and the sustained-release composition further contains stearic acid. | ||
| 地址 | Osaka JP | ||