Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ

摘要

Systems and methods provide intraluminal delivery of a bandage structure within a body lumen or hollow body organ, e.g., for treating an injured gastrointestinal tract or an esophageal hemorrhage in a non-invasive way using endoscopic visualization. The systems and methods can be sized and configured to apply a chitosan bandage structure within a body lumen or hollow body organ, to take advantage of the mucoadhesive, antimicrobial, hemostatic, and potential accelerated wound healing properties of the chitosan material.

主权项

1. A method for intraluminal delivery of a bandage structure within a body lumen or hollow body organ of the gastrointestinal tract or esophagus, comprising the steps of:
providing a delivery system comprising:
a rolled chitosan bandage having a tab and a slit formed therein, and wherein said chitosan bandage is releasably held in a rolled position by the tab inserted into the slit prior to positioning the bandage within the body lumen or the hollow body organ, has hemostatic properties, and an external active surface that reacts in the presence of a body fluid to become a strong adhesive;an expandable structure supporting said chitosan bandage wherein the tab is inserted into the slit; anda removable sheath enclosing said chitosan bandage; positioning the delivery system within said body lumen or hollow body organ so that the chitosan bandage is positioned over an injury site; removing the removable sheath when the chitosan bandage is positioned over the injury site; expanding the expandable structure to apply pressure from within the chitosan bandage so that the tab slides out of the slit and locates outside an outer surface of the bandage as the rolled chitosan bandage unfurls; adhering the chitosan bandage to said injury site; and removing the expandable structure.