PROCESS FOR THE PREPARATION OF PRAMIPEXOLE

摘要

The present invention relates to a method for economically and efficiently manufacturing pramipexole used as a treating agent of Parkinson disease, and to a novel intermediate product for the same. The manufacturing method of the present invention comprises the steps of: (i) protecting (S)- 4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine with t-butoxy carbonyl to obtain (S)-t-butyl 2-amino-4,5,6,7- tetrahydrobenzo[d]thiazole-6-yl carbamate; (ii) reacting (S)-t-butyl-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole-6-yl carbamate with a compound of chemical formula VII to obtain (S)-t-butyl-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole-6-yl(propyl)carbamate; and (iii) reacting (S)-t-butyl-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole-6-yl(propyl)carbamate with hydrochloric acid to deprotecting t-butoxycarbonyl.