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1. A compound of formula (I) or (II) wherein ring A is any one of the following groups or tautomers thereof wherein RX is halogen or CF3; RX is hydrogen or halogen; R1 is hydroxy C3-7 alkyl, imidazolyl or —RAOC(O)—RB; RA is C1-7 alkyl; RB is C1-7 alkyl, hydroxy C1-7 alkyl or carboxy C1-7 alkyl; R2 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, methylpyrazolyl or pyrimidinyl; R3 is halogen or pyridinyl; R4 is pyridinyl; R5 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, cyano, hydroxy C1-7 alkyl, oxo C1-7 alkyl, halogen or methylpyrazolyl; R6 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, hydroxy, hydroxy C1-7 alkyl, cyano C1-7 alkyl or C1-7 alkoxycarbamoyl C1-7 alkyl; R7 is hydroxy C4 alkyl; R8 is halogen, C2-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, cyano, carboxy, oxo C1-7 alkyl, halo C1-7 alkyl, hydroxy C1-7 alkyl, tetrahydro-2H-thiopyran or —C(O)—NHR20; R9 is hydrogen, hydroxy, halogen, nitro, amino, cyano, oxo, C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C1-7 alkoxy, halo C1-7 alkyl, hydroxy C1-7 alkyl, cyano C1-7 alkyl, amino C1-7 alkyl, oxo C1-7 alkyl, C1-7 alkoxy C1-7 alkyl, C1-7 alkylamino, hydroxy C1-7 alkylamino, C1-7 alkoxy C1-7 alkylamino, C1-7 alkylamino C1-7 alkyl, hydroxy C1-7 alkylamino C1-7 alkyl, hydroxyimino C1-7 alkyl, C1-7 alkoxycarbamoyl C1-7 alkyl, —C(O)R11, —OC(O)R17, —NH—C(O)R18—NH—SO2—R19 or an optionally substituted 5-12 membered carbocyclic or heterocyclic ring, each group linked to B-ring via a bond or via a C1-7 alkylene linker; R10 is hydrogen, halogen, C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, oxo, hydroxy C1-7 alkyl, oxo C1-7 alkyl or an optionally substituted 5 or 6 membered carbocyclic or heterocyclic ring; R11 is hydrogen, hydroxy, C1-7 alkyl, hydroxy C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, halo C1-7 alkyl, C1-7 alkoxy, NR12R13, or an optionally substituted 5-12 membered carbocyclic or heterocyclic ring; R12 is hydrogen, C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, C1-7 alkoxy, hydroxy C1-7 alkyl, amino C1-7 alkyl or C1-7 alkyl amino C1-7 alkyl; R13 is hydrogen or C1-7 alkyl; R14 and R15 are, independently, hydrogen or C1-7 alkyl; R14′ and R15′ are, independently, hydrogen or C1-7 alkyl, or R14′ and R15′ together form a bond; R17 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, C1-7 alkoxy, amino C1-7 alkyl, C1-7 alkylamino or C1-7 alkylamino C1-7 alkyl; R18 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, amino C1-7 alkyl, C1-7 alkylamino or C1-7 alkylamino C1-7 alkyl; R19 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl or C3-7 cycloalkyl C1-7 alkyl; R20 is hydrogen, C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl or C1-7 alkoxy; R21 is cyano C1-7 alkyl or, in case Rx is CF3, R21 can also be hydroxy C1-7 alkyl; R22 is hydroxy C1-7 alkyl; R23 is C1-7 alkyl or hydroxy C1-7 alkyl; R24 is hydroxy, halogen or C1—, alkoxy; ring B is chosen from any one of the following groups and tautomers thereof or pharmaceutically acceptable salts thereof; with the proviso that the compound of formula (II) is not any of the following compounds: (S)-3-acetyl-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(pyridin-4-yl)-1H-pyrazole-3-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(2-fluoroethyl)-2-methyl-1H-imidazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1H-imidazol-4-yl)-1,2,4-oxadiazole-5-carboxamide; (S)-5-acetyl-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide; N—((S)-1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)isoxazole-3-carboxamide; (S)-5-acetyl-N-(2-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)isoxazole-3-carboxamide; (S)—N-(2-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-2-methyl-1H-imidazole-4-carboxamide; N—((S)-1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1-hydroxyethyl)-1H-pyrazole-5-carboxamide; (R)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-methyl-1H-imidazole-4-carboxamide; (S)—N-{1-[3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl]propan-2-yl}-2-methyl-1H-imidazole-4-carboxamide; (S)—N-{1-[3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl]propan-2-yl}-1-methyl-1H-imidazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3H-imidazo[4,5-b]pyridine-5-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(pyridin-3-yl)thiazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-methyl-1-(3-oxobutyl)-1H-imidazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(3-hydroxy-3-methylbutyl)-2-methyl-1H-imidazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)imidazo[1,2-a]pyridine-2-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)imidazo[1,2-a]pyrimidine-2-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-fluoroimidazo[1,2-a]pyridine-2-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(6-methylpyridin-2-yl)-1H-imidazole-4-carboxamide; (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carboxamide; or (S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxypropan-2-yl)isoxazole-3-carboxamide. |
