Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

摘要

Systems of and methods for stimulation of neurological tissue that may generate stimulation trains with temporal patterns of stimulation is shown and disclosed herein. The temporal patterns of stimulation may include intervals between electrical pulses (the inter-pulse intervals) that change or vary over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention may provide a lower average frequency.

主权项

1. A neural stimulation device comprising:
a pulse generator configured to transmit a first temporal pattern of stimulation for application to neurological tissue having a first non-regular pulse train, the first non-regular pulse train including at least one first single pulse (first singlet) and embedded first multiple pulse groups (first n-lets), with non-regular, non-random inter-pulse intervals between the first singlet and first n-lets, as well as non-regular inter-pulse intervals within the first n-lets themselves adapted from applying a model-based optimization technique utilizing a first cost function, the first temporal pattern of stimulation having a first cost; and wherein the pulse generator is configured to transmit a second temporal pattern of stimulation for application to neurological tissue having a second non-regular pulse train, the second non-regular pulse train including at least one second single pulse (second singlet) and embedded second multiple pulse groups (second n-lets), with non-regular, non-random inter-pulse intervals between the second singlet and second n-lets, as well as non-regular inter-pulse intervals within the second n-lets themselves, the second temporal pattern adapted from applying a second model-based optimization technique having a second cost function, whereby the second temporal pattern has a second cost, the second cost function different from the first cost function.