Bispecific fusion antibodies with enhanced serum half-life

摘要

Drug compositions, fusions and conjugates are provided. The drug fusions and conjugates contain a therapeutic or diagnostic agent that is fused or conjugated to an antigen-binding fragment of an antibody that binds serum albumin. The drug compositions, fusions and conjugates have a longer in vivo half-life in comparison with the unconjugated or unfused therapeutic or diagnostic agent.

主权项

1. A drug fusion comprising moieties X′ and Y′, wherein
X′ is a polypeptide drug, with the proviso that X′ does not comprise an antibody chain or a fragment of an antibody chain; and Y′ is an immunoglobulin single variable domain that has binding specificity for serum albumin, wherein Y′ is an amino acid sequence selected from the group consisting of SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22 and SEQ ID NO:23; and wherein said drug fusion has a longer in vivo serum half-life relative to said polypeptide drug.