| 主权项 |
1. A compound of formula Iwherein
R1 is selected from the group consisting of a 5- or 6-membered heteroaromatic ring which contains 1, 2 or 3 heteroatoms independently of each other selected from N, NRN, O and S; and wherein optionally a second carbocyclic ring is condensed to said heteroaromatic ring, wherein said second carbocyclic ring is unsaturated or aromatic and 5- or 6-membered and may optionally contain 1, 2 or 3 heteroatoms independently of each other selected from N, NRN, O and S, and wherein in said second carbocyclic ring 1 or 2 —CH2-groups are optionally replaced by —N(RN)—, —C(═O)—, —S(═O)— or —S(═O)2—, and
wherein each of said heteroaromatic ring and/or second carbocyclic ring independently of each other may be optionally substituted with one or more substituents selected from LAr; andwherein said heteroaromatic ring or said second carbocyclic ring is optionally substituted with a group R2; and each RN is independently selected from the group consisting of H, C1-4-alkyl, C1-4-alkyl-C(═O)—, and C1-4-alkyl-S(═O)2—; and HetAr is selected from the group consisting of a 5- or 6-membered heteroaromatic ring which contains 1, 2 or 3 heteroatoms independently of each other selected from N, NRN, O and S;
wherein each heteroaromatic ring may be optionally substituted with one or more substituents selected from LQ; and Ar is selected from the group consisting of a phenyl ring, a tetrazolyl ring, and a 5- or 6-membered heteroaromatic ring which contains 1, 2 or 3 heteroatoms independently of each other selected from N, NRN, O and S; and wherein optionally a second carbocyclic ring is condensed to said phenyl ring or heteroaromatic ring, wherein said second carbocyclic ring is unsaturated or aromatic and 5- or 6-membered and may contain 1, 2 or 3 heteroatoms independently of each other selected from N, NRN, O and S, and wherein in said second carbocyclic ring 1 or 2 —CH2-groups are optionally replaced by —N(RN)—, —C(═O)—, —S(═O)— or —S(═O)2—, and
wherein each of said phenyl ring, heteroaromatic ring and/or second carbocyclic ring independently of each other may optionally be substituted with one or more substituents selected from LAr; andwherein said phenyl ring, a tetrazolyl ring, heteroaromatic ring or second carbocyclic ring are optionally substituted with a group T; and T is selected from the group consisting of F, Cl, Br, I, CN, OH, NO2, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C3-6-cycloalkyl, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-6-alkyl-S—, HO—C(═O)—, C1-6-alkyl-O—C(═O)—, C1-4-alkyl-C(═O)—, C3-6-cycloalkyl-C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, RNT1RNT2N—S(═O)2—, RNT1RNT2N—C(═O)—(RN)N—, heterocyclyl, heterocyclyl-O—, aryl, aryl-O—, heteroaryl and heteroaryl-O—, wherein each alkyl, alkenyl, alkynyl, and cycloalkyl group may be optionally substituted with one or more substituents independently of each other selected from F, Cl, CN, OH, C1-3-alkyl, C3-6-cycloalkyl, C1-3-alkyl-O—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—S(═O)2—, aryl, heteroaryl, and heterocyclyl, and
wherein aryl denotes phenyl or naphthyl, andwherein heteroaryl is a 5- or 6-membered aromatic carbocyclic ring which contains 1, 2, 3 or 4 heteroatoms independently of each other selected from N, NRN, O and S; andwherein heterocyclyl is a 4- to 7-membered unsaturated or saturated carbocyclic ring in which 1, 2, or 3 —CH2-groups independently of each other are replaced by NRN, O, —C(═O)—, S, —S(═O)— or —S(═O)2—, and/or in which a —CH-group is replaced by N; andwherein each aryl, heteroaryl or heterocyclyl group may be optionally substituted with one or more substituents independently of each other selected from LAr; and RNT1 is selected from the group consisting of H, C1-6-alkyl, C3-6-cycloalkyl, C1-6-alkyl-C(═O)—, C1-6-alkyl-S(═O)2, heterocyclyl, aryl and heteroaryl,
wherein each alkyl and cylcoalkyl group may be optionally substituted with one or more substituents independently of each other selected from the group consisting of F, OH, CN, C1-4-alkyl, C1-4-alkyl-O—, (RN)2N, C1-4-alkyl-S(═O)2—, C3-6-cycloalkyl, heterocyclyl, phenyl and heteroaryl; andwherein heterocyclyl is a C4-7-cycloalkyl ring in which 1 or 2 —CH2-groups independently of each other are replaced by NRN, O, C(═O), S, S(═O) or S(═O)2; andwherein heterocyclyl may be optionally substituted with one or more substituents independently of each other selected from F, C1-4-alkyl, (RN)2N, OH and C1-4-alkyl-O—; andwherein aryl is phenyl or naphthyl; andwherein heteroaryl is a 5- or 6-membered aromatic carbocyclic ring which contains 1, 2 or 3 heteroatoms independently of each other selected from N, NRN, O and S; andwherein aryl, phenyl and heteroaryl may be optionally substituted with one or more substituents LAr; and RNT2 is selected from the group consisting of H and C1-6-alkyl; or RNT1 and RNT2 are linked to form one group selected from the group consisting of a C3-5-alkylene group,
wherein 1 or 2 —CH2-groups independently of each other are replaced by NRN, O, C(═O), S, S(═O) or S(═O)2; andwhich may be optionally substituted with one or more substituents independently of each other selected from F, C1-4-alkyl, (RN)2N, OH and C1-4-alkyl-O—; LAr is selected from the group consisting of F, Cl, Br, I, CN, OH, NO2, C1-4-alkyl-, C1-4-alkyl-O—, (RN)2N—C(═O), (RN)2N—, and C1-4-alkyl-S(═O)2—, wherein each alkyl group may be optionally substituted with one or more substituents independently of each other selected from F, Cl, CN, OH and C1-3-alkyl-O—; and LP is selected from the group consisting of F and C1-3-alkyl, wherein the alkyl group may be substituted with one or more F-atoms; and LQ is selected from the group consisting of F, Cl, CN, OH, C1-4-alkyl, C3-7-cycloalkyl-, F2HC, F3C, C1-4-alkyl-O—, F2HC—O—, F3C—O— and C3-7-cycloalkyl-O—; and R2 is selected from the group consisting of F, Cl, Br, I, CN, OH, NO2, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C3-6-cycloalkyl, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-6-alkyl-S—, HO—C(═O)—, C1-6-alkyl-O—C(═O)—, C1-4-alkyl-C(═O)—, C3-6-cycloalkyl-C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—, RNT1RNT2N—(═O)—, RNT1RNT2N—S(═O)2—, RNT1RNT2N—C(═O)—(RN)N—, heterocyclyl, heterocyclyl-O—, aryl, aryl-O—, heteroaryl and heteroaryl-O—, wherein each alkyl, alkenyl, alkynyl, and cycloalkyl group may be optionally substituted with one or more substituents independently of each other selected from F, Cl, CN, OH, C1-3-alkyl, C3-6-cycloalkyl, C1-3-alkyl-O—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, C1-4-alkyl-S(═O)—, C1-4alkyl-S(═O)2—, RNT1RNT2N—S(═O)2—, aryl, heteroaryl, and heterocyclyl, and
wherein aryl denotes phenyl or naphthyl, andwherein heteroaryl is a 5- or 6-membered aromatic carbocyclic ring which contains 1, 2, 3 or 4 heteroatoms independently of each other selected from N, NRN, O and S; andwherein heterocyclyl is a 4- to 7-membered unsaturated or saturated carbocyclic ring in which 1, 2, or 3 —CH2-groups independently of each other are replaced by NRN, O, —C(═O)—, S, —S(═O)— or —S(═O)2—, and/or in which a —CH-group is replaced by N; andwherein each aryl, heteroaryl or heterocyclyl group may be optionally substituted with one or more substituents independently of each other selected from LAr; and n is an integer selected from 0, 1, 2, 3, or 4; or a salt thereof. |
