A PROCESS FOR THE PREPARATION OF CRYSTALLINE MEROPENEM TRIHYDRATE

摘要

The present invention provides a method for preparing crystalline meropenem trihydrate represented by chemical formula 1 by hydrogenating bis-meropenem represented by chemical formula 2 in a mixture of tetrahydrofuran and water only by adjusting pH using a base without using a buffer solution; and a method including an optimized reaction condition for manufacturing meropenem including the same. According to the method for preparing crystalline meropenem trihydrate of the present invention, meropenem hydrate with high purity and high yield can be prepared just by simple post-processes. Moreover, unlike meropenem trihydrate prepared by a prior method, the meropenem trihydrate of the present invention has a significantly reduced amount of residues of an organic solvent, especially acetone.