| 发明名称 | Reversibly binding resin for algal harvest and concentration | ||
| 摘要 | The present invention includes a method for harvesting or separating one or more biological cells from an aqueous feed, a stream, a suspension, or any combinations thereof by providing the aqueous feed, the stream, or the suspension comprising the one or more biological cells in a tank or a vessel; providing one or more ion-exchange resins, wherein the ion-exchange resin is an anion-exchange resin; contacting the anion-exchange resin with the aqueous feed; binding the one or more biological cells to the anion-exchange resin; releasing or eluting the bound one or more biological cells by changing the pH; and collecting the released one or more biological cells to obtain a concentrated slurry or suspension of the one or more biological cells. | ||
| 申请公布号 | US8921088(B1) | 申请公布日期 | 2014.12.30 |
| 申请号 | US201213644050 | 申请日期 | 2012.10.03 |
| 申请人 | Board of Regents, The University of Texas System | 发明人 | Poenie Martin;Jones Jessica |
| 分类号 | C12N1/00 | 主分类号 | C12N1/00 |
| 代理机构 | Chalker Flores, LLP | 代理人 | Flores Edwin S.;Chalker Daniel J.;Chalker Flores, LLP |
| 主权项 | 1. A method for harvesting or separating one or more biological cells from an aqueous feed, a stream, a suspension, or any combinations thereof comprising the steps of: (a) providing the aqueous feed, the stream, or the suspension comprising the one or more biological cells in a tank or a vessel; (b) providing one or more ion-exchange resins, wherein the ion-exchange resin is an anion-exchange resin, wherein the anion-exchange resin may be packed in a column, attached to a substrate, be in a solution, or any combinations thereof; (c) contacting the anion-exchange resin with the aqueous feed, the stream, or the suspension comprising the one or more biological cells; (d) binding the one or more biological cells to the anion-exchange resin, wherein the binding is done by maintaining a specific pH; (e) releasing or eluting the bound one or more biological cells by changing the pH by addition of an acid, a base, or one or more chemicals, wherein the change in the pH involves an increase or a decrease in the pH, wherein the release or elution of the biological cells is accomplished in a pH range of 8-13; and (f) collecting the released one or more biological cells to obtain a concentrated slurry of the one or more biological cells. | ||
| 地址 | Austin TX US | ||