Prostate tumor markers and methods of use thereof

摘要

Newly identified proteins as markers for the detection of prostate tumors, or as targets for their therapeutic treatment, affinity ligands capable of selectively interacting with said markers as well as methods for tumor diagnosis and therapy using the same.

主权项

1. A method comprising:
(a) providing a sample of a prostate tissue; (b) detecting whether the sample of the prostate tissue expresses at least one tumor marker selected from the group consisting of:
i) a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:11; andii) a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:7, wherein the detecting is performed by immunohistochemical analysis using an antibody that specifically binds to the at least one tumor marker; (c) determining that the expression of the at least one tumor marker in the sample of the prostate tissue is
(i) higher than in a non-malignant prostate tissue control sample; or(ii) same or lower than in the non-malignant prostate tissue control sample, (d) identifying the sample of the prostate tissue expressing the at least one tumor marker at a higher level than in the non-malignant prostate tissue control sample as having a prostate malignancy, and identifying the sample of the prostate tissue expressing the at least one tumor marker at the same or lower level than in the non-malignant prostate tissue control sample as not having a prostate malignancy, and (e) administering to a subject from whom the sample of the prostate tissue is obtained that expresses the at least one tumor marker at a higher level than in the non-malignant prostate tissue control sample, a monoclonal antibody that specifically binds the at least one tumor marker for treating the prostate malignancy.