The present invention provides a combination therapy which relies on a small molecule immune stimulator—cyclic-di-nucleotide (CDN)—that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM-CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens, DC recruitment and proliferation, coupled with a potent DC activation stimulus.
申请公布号
SG11201407875U(A)
申请公布日期
2014.12.30
申请号
SG11201407875U
申请日期
2013.06.07
申请人
ADURO BIOTECH;THE JOHNS HOPKINS UNIVERSITY
发明人
DUBENSKY, THOMAS, W.;LEONG, MEREDITH, LAI LING;PARDOLL, DREW, M.;KIM, YOUNG, JUN