| 发明名称 |
Infectious clones of torque teno virus |
| 摘要 |
The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen. |
| 申请公布号 |
US8921535(B2) |
申请公布日期 |
2014.12.30 |
| 申请号 |
US201012761568 |
申请日期 |
2010.04.16 |
| 申请人 |
Zoetis LLC |
发明人 |
Nitzel Gregory Paul;Ankenbauer Robert Gerard;Calvert Jay Gregory;Dunyak Donna Steuerwald;Marx Jacqueline Gayle;Oien Nancee Lois;Pearce Douglas Steven;Stoeva Mira Ivanova;Thompson James Richard |
| 分类号 |
C07H21/02;C07H21/04;C12N15/00;C12N1/00;C12N7/00;C07K14/005;C07K16/08;A61K39/00 |
主分类号 |
C07H21/02 |
| 代理机构 |
|
代理人 |
Renda Barbara L.;Donahue E. Victor |
| 主权项 |
1. A plasmid that comprises a polynucleotide that encodes a torque teno virus having a nucleotide sequence selected from the group consisting of:
(a) SEQ ID NO: 2; or (b) a nucleotide sequence that is at least 95% identical to SEQ ID NO:2. |
| 地址 |
Florham Park NJ US |
