发明名称 Glycosylated valproic acid analogs and uses thereof
摘要 Glycosylated valproic acid and its analogs are provided. In some embodiments, the glycosylated valproic acid and its analogs have improved solubility and are ideal for drug delivery to treat a variety of diseases.
申请公布号 US8921533(B2) 申请公布日期 2014.12.30
申请号 US201213557528 申请日期 2012.07.25
申请人 Chromatin Technologies 发明人 Heyman Norman S.;Shull Brian K.
分类号 C07H13/04;C07H15/18;A61K31/7028 主分类号 C07H13/04
代理机构 Wilmer Cutler Pickering Hale and Dorr LLP 代理人 Wilmer Cutler Pickering Hale and Dorr LLP
主权项 1. A compound of formula IV or V: wherein R1 is a naturally occurring saccharide linked at the anomeric carbon of the saccharide, provided R1 is not glucuronate; each of R6 and R7 is independently a linear or branched, saturated or partially unsaturated aliphatic C2-C20 hydrocarbon chain; each of R8 and R9 is independently a linear or branched aliphatic C2-C20 hydrocarbon chain which is optionally substituted with a C3-C9 aliphatic or aromatic cyclohydrocarbon or heterocyclic group or having 1-3 substituents independently selected from the group consisting of halogen atoms, amino, hydroxy, carboxylic acid group, ester, amide, and cyano wherein one or more of the hydroxy, carboxylic acid, amine, or amide group is optionally glycosylated with a saccharide group; and Y is a bond or —CH2-aryl-O—, wherein the aryl group is optionally substituted with one or more substituents independently selected from C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 thioalkyl, —N(C1-C3 alkyl)(C1-C3 alkyl), —NH(C1-C3 alkyl), —NH2, —NO2, and —CN; or a pharmaceutically acceptable salt thereof, wherein the compound is predominantly an individual anomer.
地址 New York NY US