主权项 |
1. A compound of formula IV or V: wherein R1 is a naturally occurring saccharide linked at the anomeric carbon of the saccharide, provided R1 is not glucuronate; each of R6 and R7 is independently a linear or branched, saturated or partially unsaturated aliphatic C2-C20 hydrocarbon chain; each of R8 and R9 is independently a linear or branched aliphatic C2-C20 hydrocarbon chain which is optionally substituted with a C3-C9 aliphatic or aromatic cyclohydrocarbon or heterocyclic group or having 1-3 substituents independently selected from the group consisting of halogen atoms, amino, hydroxy, carboxylic acid group, ester, amide, and cyano wherein one or more of the hydroxy, carboxylic acid, amine, or amide group is optionally glycosylated with a saccharide group; and Y is a bond or —CH2-aryl-O—, wherein the aryl group is optionally substituted with one or more substituents independently selected from C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 thioalkyl, —N(C1-C3 alkyl)(C1-C3 alkyl), —NH(C1-C3 alkyl), —NH2, —NO2, and —CN; or a pharmaceutically acceptable salt thereof, wherein the compound is predominantly an individual anomer. |