Synthetic, defined fibronectin mimetic peptides and surfaces modified with the same

摘要

The present invention discloses compositions for applications that mimic fibronectin coated surfaces. Advantageously, such compositions provide an animal free (xeno-free, and human-component-free), synthetic, chemically defined surface that mimics at least one of the functionalities of fibronectin.

主权项

1. A compound comprising at least two regions of a fibronectin cell-binding domain joined by a flexible linker wherein at least one region comprises amino acid sequence GRGDSP (SEQ ID NO: 1) and another region comprises X1X2X3X4X5X6X7X8X9X10X11X12X13RX15PX17SRNX21X22TLTX26 (SEQ ID NO: 2) wherein
X1 denotes K or is absent, X2 denotes K or is absent, X3 denotes K or is absent, X4 denotes K or is absent, X5 denotes K or is absent, X6 denotes K, X7 denotes S, V, A, G or is absent X8 denotes G, A or is absent X9 denotes R or G X10 denotes P, A, Q or G X11 denotes R or K X12 denotes E, Q, W, A or G X13 denotes D or E X15 denotes V, L or I X17 denotes H or P X21 denotes S, T or G X22 denotes I or L and X26 denotes N or H; and wherein the compound is less than 100 amino acids.