| 摘要 |
PROBLEM TO BE SOLVED: To provide an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6) binding ability possessing compound.SOLUTION: The compound of general formula (I), its salt, its solvate, or prodrug thereof possesses S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6) binding ability and is useful for prevention and/or treatment of rejection reaction against transplantation, graft-versus-host disease, autoimmune disease, allergic disease, etc. (In which, ring A is a cyclic group; ring B is a cyclic group which may have a substituent; X is a main-chain spacer or the like having an atomic number of 1 to 8; Y is a main-chain spacer or the like having an atomic number of 1 to 10; n is 0, 1; when n is 0, m is 1, and Ris a hydrogen atom, a substituent; when n is 1, m is an integer of 0 to 7, and Ris a substituent, and when m is 2 or more Rmay be the same or different). |
