METHOD AND COMPOSITION FOR ADMINISTRATION OF TRPV1 AGONIST

摘要

PROBLEM TO BE SOLVED: To provide additional methods and compositions for administration of capsaicin and other TRPV1 agonists.SOLUTION: Compositions that contain a TRPV1 agonist, such as capsaicin, and a solvent system are provided. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. A method for using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided. The invention provides a method for delivering a TRPV1 agonist to the epidermis and dermis underlying a 1 cmarea of a skin or mucosal surface of a mammal including a step of contacting the area with a composition comprising the TRPV1 agonist and at least one penetration enhancer, where, 30 minutes after the contacting step, at least about 3 nanomoles of the TRPV1 agonist is retained in the epidermis and dermis.