Tissue-Engineered Vascular Graft and Its Fabrication Approach

摘要

Tissue-engineered vascular graft is designed to be used in cardiovascular surgeries, especially in coronary artery bypass grafting and peripheral vessels reconstruction procedures. Two-phase electrospinning technique was employed to fabricate a biodegradable polymer graft composed of the porous tubular scaffold supplemented by biologically active molecules, incorporated directly into the matrix walls in order to promote regeneration process of the patient's own vessel wall.

主权项

1. A method of producing a tissue-engineered vascular graft, the method comprising:
applying an electrospining process to fabricate biodegradable polymer scaffold structures having porous walls; incorporating in the scaffold structures biological molecules of at least one of: vascular endothelial growth factor (VEGF), fibroblast growth factor beta (b-FGF) and stromal derived factor-1alpha (SDF-1α), or heparin molecules; and forming the graft using the scaffold structures containing the incorporated molecules.