| 发明名称 |
INHIBITOR OF TRPM-4 ION CHANNEL FOR TREATING OR PREVENTING NEURODEGENERATION |
| 摘要 |
The invention relates to a compound which is effective in inhibiting the function of the TRPM4 ion channel and the use of such compound in treating or preventing a neurodegenerative disease, such as Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, or a myotrophic lateral sclerosis, in a subject. The invention also provides a pharmaceutical composition comprising a TRPM4 inhibitory compound. The invention further relates to in vitro methods for identifying pharmaceutically active compounds that are useful for treating or preventing a neurodegenerative disease. |
| 申请公布号 |
US2014378548(A1) |
申请公布日期 |
2014.12.25 |
| 申请号 |
US201214369624 |
申请日期 |
2012.12.21 |
| 申请人 |
UNIVERSITATSKLINIKUM HAMBURG-EPPENDORF ;UNIVERSITAT DES SAARLANDES ;UNIVERSITE DE GENEVE |
发明人 |
Friese Manuel;Schattling Benjamin;Steinbach Karin;Freichel Marc;Flockerzi Veit;Vennekens Rudi;Merkler Doron |
| 分类号 |
A61K31/18;C12Q1/68 |
主分类号 |
A61K31/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Compound which is effective in inhibiting the function of a TRPM4 ion channel for use in a method of treating or preventing a neurodegenerative disease in a subject. |
| 地址 |
Hamburg DE |
