| 主权项 |
1. A tricyclic compound represented by: wherein: T, Y and Z are independently selected from the group consisting of: CH or N, and wherein one or two of T, Y and Z is nitrogen; D is a 5-6 membered heterocyclic, carbocyclic or heteroaromatic ring; X is selected from the group consisting of: +—W1—*, +—W2—C(RD3RD4)—*, +—W2—C(O)—*, +—C(RD1RD2)—W3—*, in which the attachment points are indicated by + and * in X and in Formula I; W1 is selected from the group consisting of: O, N(RN1) or S; W2 is selected from the group consisting of: O or N(RN2); W3 is selected from the group consisting of: O or N(RN3); A is a ring selected from the group consisting of: phenyl, a 5-6 membered heteroaryl having 1, 2 or 3 heteroatoms each selected from S, N or O, and a 4-7 membered heterocycle having 1, 2 or 3 heteroatoms each selected from N or O; RA1 is selected, independently for each occurrence, from the group consisting of: hydrogen, hydroxyl, cyano, halogen, C1-4alkyl or C1-3alkoxy; wherein C1-4alkyl, or C1-3alkoxy may be optionally substituted by one or more fluorines; n is 1 or 2; RA2 is selected from the group consisting of: hydrogen, RiRjN—, heterocyclyl, heterocyclyloxy, heterocyclyl-(NRa)—; wherein said heterocyclyl may optionally be substituted by one or more substituents selected from Rg and wherein if said heterocyclyl contains a —NH moiety that nitrogen may optionally be substituted by one or more groups Rh; or RA2 is selected from the group consisting of: C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C3-6alkenyloxy, C3-6alkynyloxy, C3-6cycloalkoxy, (wherein w is 0, 1 or 2), C1-6alkyl-N(Ra)—, C1-6alkyl-N(Ra)-carbonyl-, C1-6alkylcarbonyl-N(Ra)—, C1-6alkyl-N(Ra)-carbonyl-N(Ra)—, C1-6alkyl-N(Ra)—SO2—, C1-6alkyl-S2—N(Ra)—, C1-6alkoxycarbonyl-N(Ra)—, C1-6alkylcarbonyl-N(Ra)—C1-6alkyl-, C1-6alkyl-N(Ra)-carbonyl-C1-6alkyl-, C1-6alkoxyC1-6alkyl-; wherein C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C3-6alkenyloxy, C3-6alkynyloxy, C3-6cycloalkoxy, C1-6alkyl-N(Ra)-carbonyl-, C1-6alkylcarbonyl-N(Ra)—, C1-6alkyl-N(Ra)-carbonyl-N(Ra)—, C1-6alkyl-N(Ra)—SO2—, C1-6alkyl-SO2—N(Ra)—, C1-6alkoxycarbonyl-N(Ra)—, C1-6alkylcarbonyl-N(Ra)C1-6alkyl-, C1-6alkyl-N(Ra)-carbonyl-C1-6alkyl-, C1-6alkoxy-C1-6alkyl may optionally be substituted by RP, phenyl, phenoxy, heteroaryl, heteroaryloxy, heteroaryl-(NRa)—, heterocyclyl, heterocyclyloxy or heterocyclyl-N(Ra)—; and wherein said heteroaryl or phenyl may optionally be substituted with one or more substituents selected from Rf; and wherein said heterocyclyl may optionally be substituted by one or more substituents selected from Rg; and wherein if said heterocyclyl contains a —NH moiety that nitrogen may optionally be substituted by one or more groups Rh; RD1 and RD2 are each independently selected from the group consisting of: hydrogen, fluorine, hydroxyl, C1-2alkyl or C1-2alkoxy; wherein the C1-2alkyl and C1-2alkoxy may optionally be substituted by one or more fluorine atoms or a group selected from cyano or hydroxyl; RD3 and RD4 are each independently selected from the group consisting of: hydrogen, fluorine, hydroxyl, cyano, C1-2alkyl or C1-2alkoxy; wherein the C1-2alkyl and C1-2alkoxy may optionally be substituted by one or more fluorine atoms or a group selected from cyano, hydroxyl or N(RaRb); RN1 is selected from the group consisting of: hydrogen or C1-2alkyl; RN2 is selected from the group consisting of: hydrogen or C1-2alkyl; RN3 is selected from the group consisting of: hydrogen, C1-3alkyl or C1-2alkylcarbonyl; wherein the C1-3alkyl and C1-2alkylcarbonyl may optionally be substituted by one or more fluorine atoms or a group selected from cyano, hydroxyl or N(RaRb); Ra and Rb are independently selected, for each occurrence, from the group consisting of: hydrogen and C1-3alkyl; wherein C1-3alkyl may optionally be substituted by one or more substituents selected from: fluorine, cyano, oxo and hydroxyl; or Ra and Rb, together with the nitrogen to which they are attached, may form a 4-6 membered heterocyclic ring which may have an additional heteroatom selected from O, S, or N; and wherein the 4-6 membered heterocyclic ring may optionally be substituted by one or more substituents selected from the group consisting of: fluorine, cyano, oxo or hydroxyl; Rf is independently selected, for each occurrence, from the group consisting of: RP, hydrogen, C1-6alkyl, C3-6cycloalkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C1-6alkyl-S(O)w— (wherein w is 0, 1 or 2), C1-6alkylcarbonyl-N(Ra)—; C1-6alkoxycarbonyl-N(Ra)—; and wherein C1-6alkyl, C3-6cycloalkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C1-6alkyl-S(O)w—, C1-6alkylcarbonyl-N(Ra)—, C1-6alkoxycarbonyl-N(Ra)— may be optionally substituted by one or more substituents selected from RP; Rg is independently selected for each occurrence from the group consisting of: RP, hydrogen, oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, (wherein w is 0, 1 or 2), C1-6alkylcarbonyl-N(Ra)—, C1-6alkoxycarbonyl-N(Ra)—; wherein C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C1-6alkylcarbonyl-N(Ra)—, C1-6alkoxycarbonyl-N(Ra)— may be optionally substituted by one or more substituents selected from RP; Rh is independently selected for each occurrence from the group consisting of: hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl, C1-6alkyl-S(O)2—, C1-6alkoxycarbonyl-, RiRjN-carbonyl-, RiRjN—SO2—; wherein C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl, C1-6alkyl-S(O)2—, C1-6alkylcarbonyl- may optionally be substituted by one or more substituents selected from RP; Ri and Rj, are selected independently for each occurrence from the group consisting of: hydrogen, C1-4alkyl and C3-6cycloalkyl; wherein C1-4alkyl and C3-6cycloalkyl may be optionally substituted by one or more substituents selected from fluorine, hydroxyl, cyano, RaRbN—, RaRbN-carbonyl-, C1-3alkoxy; or Ri and Rj taken together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring which may have an additional heteroatom selected from O, S, or N, optionally substituted on carbon by one or more substituents selected from the group consisting of: fluorine, hydroxyl, oxo, cyano, C1-6alkyl, C1-6alkoxy, RaRbN—, RaRbN—SO2—, RaRbN-carbonyl-; and wherein said C1-6alkyl or C1-6alkoxy may optionally be substituted by fluorine, hydroxyl or cyano; and optionally substituted on nitrogen by one or more substituents selected from the group consisting of: C1-6alkyl, RaRbN-carbonyl-; and wherein said C1-6alkyl may be optionally substituted by fluorine, hydroxyl, cyano; RP is independently selected, for each occurrence, from the group consisting of: halogen, hydroxyl, cyano, C1-6alkoxy, RiRjN-carbonyl-, RiRjN—SO2—, R1RjN-carbonyl-N(Ra)—; and pharmaceutically acceptable salts, stereoisomers, esters and prodrugs thereof. |
