CONFORMATIONS OF DIVERGENT PEPTIDES WITH MINERAL BINDING AFFINITY

摘要

A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.;

主权项

1. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier, and an effective amount a compound having a formula 2:
[H2NAGYAsp]B  (2), wherein G is one selected from a group consisting of a polyamindoamine dendrimer (PAMAM), a polyester type dendrimer, a polyglycerol dendrimer, a triazine based dendrimer, a poly(propyleneimine)dendrimer, a Newkome-type dendrimers and a polylysine dendrimer, the sum of A and B is (4×2Y), where A, B and Y are natural numbers and Y is a number of generation, and Asp represents an aspartic acid.