| 主权项 |
1. A nanoparticle aggregate comprising:
(i) a plurality of interior nanoparticle cores bound together and enclosed by a plurality of exterior nanoparticle cores bound together, wherein at least a portion of said plurality of interior nanoparticle cores are bound to said plurality of exterior nanoparticle cores; (ii) a plurality of interior polyvalent linkers binding said interior nanoparticle cores together, binding said exterior nanoparticle cores together, and binding said portion of said interior nanoparticle cores to said exterior nanoparticle cores, wherein each of said plurality of interior polyvalent linkers comprises a central polyvalent moiety covalently bound to at least two nanoparticle linkers, each of said nanoparticle linkers bound to one of said interior nanoparticle cores or one of said exterior nanoparticle cores; (iii) a plurality of exterior polyvalent linkers binding at least one capping substituent to at least a portion of said exterior nanoparticle cores, wherein each of said plurality of exterior polyvalent linkers comprises:
(a) said central polyvalent moiety covalently bound to at least one of said nanoparticle linkers, said nanoparticle linkers bound to one of said exterior nanoparticle cores; and(b) at least one capping linker bound to said capping substituent, wherein said exterior polyvalent linker comprises at least two nanoparticle linkers and capping linkers combined. |
