SMALL MOLECULE ACTIVATORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS AND METHODS OF USE

摘要

Provided herein are small molecule activators of calcium-activated chloride channels. These small molecules may be used for treatment of diseases and disorders that are treatable by activating calcium-activated chloride channels, such as cystic fibrosis, disorders related to salivary gland dysfunction (for example, Sjogren's syndrome and dysfunction following radiation injury), dry eye syndrome, and intestinal hypomotility.

主权项

1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of structure (I):or a stereoisomer, tautomer, solvate, or pharmaceutically acceptable salt thereof, wherein
R1, R2 and R3 are each independently alkoxy; R4 is aralkyl, heteroaralkyl, heterocyclylalkyl or alkoxyalkyl; and R5 and R6 are each independently hydrogen, alkoxy or halo.