发明名称 |
PROCESS FOR PREPARING STABLE PHARMACEUTICAL COMPOSITIONS OF COMPOUNDS SUSCEPTIBLE TO HYDROLYSIS |
摘要 |
The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range −5±1° C. to −5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution. |
申请公布号 |
US2014378407(A1) |
申请公布日期 |
2014.12.25 |
申请号 |
US201214377047 |
申请日期 |
2012.03.29 |
申请人 |
Khattar Dhiraj;Khanna Rajesh;Motwani Sanjay;Garg Minakshi;Chandel Vikas;Yadav Mukti;Kumar Kyama Vijay;Bhandari Vikas |
发明人 |
Khattar Dhiraj;Khanna Rajesh;Motwani Sanjay;Garg Minakshi;Chandel Vikas;Yadav Mukti;Kumar Kyama Vijay;Bhandari Vikas |
分类号 |
A61K31/706;A61K47/02;A61K47/26;A61K31/4184;A61K9/19 |
主分类号 |
A61K31/706 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Gurgason IN |