SIGNATURE FOR THE DIAGNOSIS OF LUNG CANCER AGGRESSIVENESS AND GENETIC INSTABILITY

摘要

The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of said patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, said signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the said expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness and from the said comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.

主权项

1. A method for diagnosing aggressiveness of a lung cancer in a patient, comprising the steps of:
a) detecting from a biological sample of said patient an expression profile of the DNA replication stress gene signature, said signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes; b) comparing the expression profile of step a) with at least one reference expression profile, and c) diagnosing aggressiveness or non-aggressiveness of the lung cancer from the said comparison.