PREPARATION METHOD OF 3,7,11- TRIMETHYLDODEC -2,4,6,10-TETRAENE-1-YL-PHOSPHONIC SALT

摘要

Provided in the present invention is a preparation method for a phosphonic salt, comprising the step of: reacting 3,7,11-trimethyldodec-1,4,6,10-tetraene-3-ol with triarylphosphine and an acid in an alcohol solvent at 50-100° C. to form the phosphonic salt, wherein the acid is a sulfamic acid or methanesulfonic acid, and the alcohol solvent is a straight chain monohydric alcohol containing 1-5 carbon atoms. The method is performed in nearly neutral conditions, greatly reducing the generation of impurities and greatly obtaining phosphonic salt with an increased E content. The yield of lycopene obtained by using the phosphonic salt as a raw material is high.

主权项

1. A preparation method of phosphonic salt of Formula I, comprising reacting 3,7,11-trimethyldodec-1,4,6,10-tetraene-3-ol of Formula II with triarylphosphine and an acid in an alcohol solvent at a temperature of 50˜100° C. to produce a phosphonic salt of Formulawherein the acid is sulfamic acid or methanesulphonic acid, the alcohol solvent is a straight-chain monohydric alcohol containing C1˜C5, R is phenyl, X is an anion of sulfamic acid or methanesulphonic acid.