Pharmaceutical Composition Comprising miRNA-100 And Its Use In The Modulation of Blood Vessel Growth and Endothelial Inflammation

摘要

Disclosed is a pharmaceutical composition comprising a miRNA-100 molecule or an antagomir thereof or a variant thereof for use as a medicament for the positive or negative modulation of blood vessel growth and vascular inflammation wherein the miRNA-100 or the miRNA antagomir has a homology of at least 85% to any of SEQ ID NO: 1, 2, 3 and/or 9.

主权项

1. A method of administering a pharmaceutical composition comprising a miRNA-100 molecule or an antagomir thereof or a variant thereof for modulating blood vessel growth, for modulating proliferation, tube formation and sprouting activity of endothelial cells to form new blood vessels, or for modulating adhesion molecule expression of these cells for treating a vascular disease selected from the group consisting of peripheral vascular occlusive disease, coronary artery disease, cerebrovascular disease, vasculitis, artherosclerosis, vascular remodeling in response to injury and restenosis, wherein the miRNA-100 has a homology of at least 85% to SEQ ID NO: 9 or the miRNA-100 antagomir has a homology of at least 85% to SEQ ID NO: 3.