| 发明名称 |
FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY |
| 摘要 |
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 anti body in vivo. |
| 申请公布号 |
US2014377251(A1) |
申请公布日期 |
2014.12.25 |
| 申请号 |
US201214114832 |
申请日期 |
2012.05.02 |
| 申请人 |
Diluzio Willow;Truong Nobel T.;Varga Csanad M.;Palaniappan Vaithianathan;Brown Jason;Fox Irving H.;Scholz Catherine |
发明人 |
Diluzio Willow;Truong Nobel T.;Varga Csanad M.;Palaniappan Vaithianathan;Brown Jason;Fox Irving H.;Scholz Catherine |
| 分类号 |
A61K47/26;A61K47/18;A61K39/395 |
主分类号 |
A61K47/26 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A stable formulation comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one free amino acid, wherein the formulation is in solid form, and the molar ratio of non-reducing sugar to anti-α4β7 antibody (mole:mole) is greater than 600:1, wherein the free amino acid to antibody molar ratio is at least 250:1. |
| 地址 |
Westford MA US |
