| 发明名称 |
COMPOSITIONS AND METHODS FOR DELIVERING INHIBITORY OLIGONUCLEOTIDES |
| 摘要 |
The present invention features compositions and methods that make use of complexes comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, in delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject. |
| 申请公布号 |
US2014377179(A1) |
申请公布日期 |
2014.12.25 |
| 申请号 |
US201414220726 |
申请日期 |
2014.03.20 |
| 申请人 |
The United States of America,as represented by the Secretary, Department of Health & Human Services |
发明人 |
Arya Bira;Olkhanud Purevdorj;Espinoza Juan |
| 分类号 |
A61K47/48;A61K31/713;C07K14/52;C07K14/005 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A complex or a fusion molecule comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide comprises a cell surface receptor ligand. |
| 地址 |
Rockville MD US |
