| 主权项 |
1. Compounds of the formula I in which R1 denotes Ar or Het, R2 denotes furyl, thienyl, pyrrolyl, thiadiazolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl or tetrazolyl which is unsubstituted or mono- or disubstituted by Hal, A, [C(R3)2]pCyc, [C(R3)2]pOR3, [C(R3)2]pN(R3)2, [C(R3)2]pAr, [C(R3)2]pHet1, NO2, CN, [C(R3)2]pCOOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)nA, COHet1, O[C(R3)2]mN(R3)2, O[C(R3)2]pHet1, NHCOOA, NHCON(R3)2, NHCOO[C(R3)2]mN(R3)2, NHCOO[C(R3)2]pHet1, NHCONH[C(R3)2]m—N(R3)2, NHCONH[C(R3)2]pHet1, OCONH[C(R3)2]mN(R3)2, OCONH[C(R3)2]pHet1, CHO, COA, ═S, ═NR3 and/or ═O, R3 denotes H or A′, Ar denotes phenyl or naphthyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R3)2]pOR3, [C(R3)2]pN(R3)2, [C(R3)2]pHet1, NO2, CN, [C(R6)2]pCOOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)nA, S(O)nHet1, COHet1, O[C(R3)2]mN(R3)2, O[C(R3)2]pHet1, NHCOOA, NHCON(R3)2, NHCOO[C(R3)2]mN(R3)2, NHCOO[C(R3)2]pHet1, NHCONH[C(R3)2]niN(R3)2, NHCONH[C(R3)2]pHet1, OCONH[C(R3)2]mN(R3)2, OCONH[C(R3)2]p-Het1, CHO and/or COA, Het denotes furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzimidazolyl, indazolyl, quinolyl, 1,3-benzodioxolyl, benzothiophenyl, benzofuranyl, imidazopyridyl, dihydroindolyl, quinoxalinyl, benzo[1,2,5]thiadiazolyl or furo[3,2-b]pyridyl which is unsubstituted or mono- or disubstituted by Hal, A, [C(R3)2]pOR3, [C(R3)2]pN(R3)2, [C(R3)2]pHet1, NO2, CN, [C(R6)2]pCOOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)nA, COHet1, O[C(R3)2]mN(R3)2, O[C(R3)2]pHet1, NHCOOA, NHCON(R3)2, NHCOO[C(R3)2]mN(R3)2, NHCOO[C(R3)2]pHet1, NHCONH[C(R3)2]mN(R3)2, NHCONH[C(R3)2]pHet1, OCONH[C(R3)2]mN(R3)2, OCONH[C(R3)2]pHet1, CHO, COA, ═S, ═NR3 and/or ═O, Het1 denotes dihydropyrrolyl, pyrrolidinyl, azetidinyl, oxetanyl, tetrahydro-imidazolyl, dihydropyrazolyl, tetrahydropyrazolyl, tetrahydrofuranyl, dihydropyridyl, tetrahydropyridyl, piperidinyl, morpholinyl, hexa-hydropyridazinyl, hexahydropyrimidinyl, [1,3]dioxolanyl, tetrahydropyranyl, pyrazolyl, pyridyl or piperazinyl, which is unsubstituted or mono- or disubstituted by Hal, CN, OH, OA, COOA, CONH2, S(O)nA, S(O)nAr, COA, A and/or ═O, A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH— and/or CH2-groups may be replaced by N—, O- and/or S-atoms and wherein 1-7H-atoms may be replaced by F or Cl, Cyc denotes cyclic alkyl with 3-7 C-atoms, which is unsubstituted or monosubstituted by [C(R3)2]pOH, A′ denotes unbranched or branched alkyl with 1, 2, 3 or 4 C-atoms, Hal denotes F,
Cl, Br or I, n denotes 0,
1 or 2, m denotes 1,
2 or 3, p denotes 0, 1, 2, 3 or 4,
and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. |
