COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

摘要

PROBLEM TO BE SOLVED: To provide inhibitors of ATR (ATM and Rad3 related) protein kinase, which acts with ATM (ataxia telangiectasia mutated) kinase and many other proteins to regulate a cell's response to DNA damage, commonly referred to as the DNA damage response (DDR).SOLUTION: The present invention relates to pyrazine compounds of the formula I in the figure, or pharmaceutically acceptable salts thereof. (R1 is a 5-6 membered monocyclic aromatic or heteroaromatic ring having 0-4 heteroatoms selected from N, O and S; Ris -Q or -Q-Q; Q is a 3-7 membered monocyclic saturated or unsaturated non-aromatic ring having 0-4 heteroatoms selected from N, O and S; Qis a 3-8 membered monocyclic saturated or unsaturated ring having 0-4 heteroatoms selected from N, O and S; and Q and Qmay form a fused bicyclic ring).