主权项 |
1. A method for preparation of (2-hydroxyl-3-oxo-cyclopent-1-enyl)-acetic acid esters of formula Iwherein R is an alkyl group, or an alkyl phenyl group, said method comprising the steps of:
a) selecting 3-halogeno-cyclopentane-1,2-diones of formula II as a starting compoundwherein:
X is a halogen atom, and Y is H, or a substituted Si atom with R1, R2, R3-substitutions, where R1, R2 and R3 are all CH3; or R1 and R2 are both CH3, and R3=tBu;
b) in presence of a catalyst, coupling the starting compounds of formula II with Zn-derivatives of bromoacetic acid esters of formula III, wherein R is alkyl or an alkyl phenyl group; and
c) Obtaining (2-hydroxyl-3-oxo-cyclopent-1-enyl)-acetic acid esters of formula I. |