NPP1 FUSION PROTEINS

摘要

The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.

主权项

1. A host cell comprising a recombinant nucleic acid that encodes a NPP1 fusion protein, wherein the NPP1 fusion protein comprises an NPP1 component, a targeting moiety, and an Fc region of an immunoglobulin, wherein a) the NPP1 component comprises the cystein-rich region and the C-termus catalytic domain of NPP1, b) the targeting moiety and the Fc region are each located C-terminally to the NPP1 component, and c) the NPP1 fusion protein has NPP1 enzymatic activity.