In situ-formed bioactive tissue adherent films of absorbable crystallizable polymers

摘要

An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.

主权项

1. An in situ film-forming, sprayable solution comprising at least one absorbable, low-crystallinity, segmented copolymer in a methyl acetate solvent, the solution further comprising at least one bioactive agent selected from the group consisting of antimicrobial agents, anesthetic agents, antiviral agents, anti-inflammatory agents, hemostatic agents, and antineoplastic agents.