主权项 |
1. A compound of Formula I:wherein
R1 and R2 are independently selected from H, OH, halo, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, (R16)(R17)N—C1-4 alkylene-O—, or R1 and R2 are linked together to form a —O-ethylene-O— group, wherein
R16 and R17 are independently C1-4 alkyl or benzyl, or R16 and R17 together with nitrogen form a ring selected fromwherein
X is N or O and R18 is H or unsubstituted phenyl; and wherein at least one of R1 and R2 is not H; R3 is selected from whereinR6, R7, R8, R9, and R10, are independently selected from H, halo, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, and S(O)2—C1-6 alkyl;R20 is H; andn is 1-4 R4 is C1-6 alkyl; R4′ is H or C1-6 alkyl; and R5 is H, C1-6 alkyl, and C(O)O(C1-4 alkyl), C(O)(C1-4 alkyl), or C(O)(C1-4haloalkyl); or R3 and R5 together with nitrogen form a ring selected fromwherein
R11 and R12, are independently selected from H, halo, and C1-6 haloalkyl, and Y is CH or N; R13.is H, C1-6 alkyl, C3-6 cycloalkyl, unsubstituted phenyl or phenyl substituted with C1-6 haloalkyl, or unsubstituted benzyl R14 and R15 are independently selected from H and halo;R19 is H, andpharmaceutically acceptable salts thereof,with the proviso that the following racemic mixtures of compounds are excluded |