| 发明名称 |
COMBINATION THERAPY |
| 摘要 |
The present disclosure relates to a method for treatment or prevention of diseases have an increased level of insulin-like growth factor I (IGF-I). The method comprises administration of a growth hormone (GH) variant having antagonistic activity in combination with an oligonucleotide targeted to growth hormone receptor (GHR) to a subject in need. |
| 申请公布号 |
US2014378379(A1) |
申请公布日期 |
2014.12.25 |
| 申请号 |
US201314376390 |
申请日期 |
2013.02.04 |
| 申请人 |
Antisense Therapeutics Ltd |
发明人 |
Tachas George |
| 分类号 |
A61K38/27;A61K31/7115;A61K31/712 |
主分类号 |
A61K38/27 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treatment or prevention of a disease caused by and/or associated with an increased level of insulin-like growth factor I (IGF-I), the method comprising administering to a subject in need thereof, a growth hormone (GH) variant having GH antagonistic activity in combination with an oligonucleotide 8 to 80 nucleobases in length targeted to a nucleic acid encoding growth hormone receptor (GHR) so as to inhibit expression of the GHR, thereby reducing the level of IGF-I in the subject. |
| 地址 |
Toorak, Victoria AU |
