| 摘要 |
The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema. |
| 主权项 |
1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof,wherein:
Z is selected from the group consisting of C1-C3alkyl, —O—(C1-C3alkyl) and halo; m is 0, 1, 2 or 3; X is S, NH or —N—(C1-C3alkyl), Y is—(CH2)n—, wherein n is 0, 1, 2, or 3; Ar is phenyl or heteroaryl, either of which is optionally substituted with one or more substituents selected from the group consisting of CN, halo, C1-C3alkyl, C1-C3alkoxy and C1-C3haloalkyl; and Ar′ is phenyl or heteroaryl, either of which is optionally substituted with one or more substituents selected from the group consisting of CN, halo, C1-C3alkyl, C1-C3alkoxy and C1-C3haloalkyl. |
