ANTI-KDR ANTIBODIES AND METHODS OF USE

摘要

The present invention provides anti-KDR monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of a variety of cancers, rheumatoid arthritis, diabetic retinopathy and other diseases associated with aberrant VEGF or KDR expression and/or activity.

主权项

1. An isolated antibody, or an antigen-binding fragment thereof, that binds to KDR, comprising (i) a heavy chain variable region comprising the VHCDR1 region set forth in SEQ ID NO:3 or 11, the VHCDR2 region set forth in SEQ ID NO:4 or 12, and the VHCDR3 region set forth SEQ ID NO:5; and (ii) a light chain variable region comprising the VLCDR1 region set forth in SEQ ID NO:6, the VLCDR2 region set forth in SEQ ID NO:7, and the VLCDR3 region set forth in SEQ ID NO: 8;
or a variant of said antibody, or an antigen-binding fragment thereof, comprising heavy and light chain variable regions identical to the heavy and light chain variable regions of (i) and (ii) except for up to 8 amino acid substitutions in said CDR regions.