NOVEL VASCULAR LEAKAGEAGE INHIBITOR

摘要

The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present invention inhibits the apoptosis of vascular endothelial cells, inhibits the formation of actin stress fibers induced by VEGF, and enhances the cortical actin ring structure, thereby inhibiting vascular leakage. Accordingly, the vascular leakage inhibitor of the present invention can prevent or treat various diseases caused by vascular leakage. Since the vascular leakage inhibitor of the present invention is synthesized from commercially available or easily synthesizable pregnenolones, it has remarkably superior feasibility of commercial synthesis.

主权项

1. A compound represented by Chemical Formula 1 as a ginsenoside Rk1 analog or a pharmaceutically acceptable salt thereof: wherein X is oxygen or sulfur; R1 is hydrogen, halo, C3-10 cycloalkyl, C3-10 cycloalkenyl, C2-10 heterocycloalkyl containing oxygen, sulfur or nitrogen as a heteroatom, C3-15 heterocycloalkylalkyl containing oxygen, sulfur or nitrogen as a heteroatom, C3-10 heterocycloalkenyl containing oxygen, sulfur or nitrogen as a heteroatom, C6-10 aryl, C6-15 aralkyl, C6-15 alkaryl or C3-15 heteroaryl containing oxygen, sulfur or nitrogen as a heteroatom; R2 and R3 are independently hydrogen or C1-10 alkyl; R4 is hydrogen, hydroxy or C1-10 alkyl; R5 is hydrogen, hydroxyl, C1-30 alkyl, C3-10 cycloalkyl, C2-30 alkenyl, C3-10 cycloalkenyl, C2-30 alkynyl, C2-10 heterocycloalkyl containing oxygen, sulfur or nitrogen as a heteroatom, C3-15 heterocycloalkylalkyl containing oxygen, sulfur or nitrogen as a heteroatom, C2-30 alkoxyalkyl, C3-30 alkoxyalkoxyalkyl, C3-10 heterocycloalkenyl containing oxygen, sulfur or nitrogen as a heteroatom, C1-20 alcohol, C1-20 alkenol, C2-30 acyl, C1-10 amide, C1-10 amine, C2-15 ester, sulfate, carboxyl, C3-20 carboxyalkyl, C3-20 carboxyalkenyl, C3-20 alkylcarboxyl, C3-20 alkenylcarboxyl, C3-20 alkylcarboxyalkyl, C3-20 alkylcarboxyalkenyl, C3-20 alkenylcarboxyalkyl, C4-20 alkenylcarboxyalkenyl, C6-30 aryl, C6-30 aralkyl, C6-30 alkaryl, C3-30 heteroaryl containing oxygen, sulfur or nitrogen as a heteroatom or C6-30 arylcarbonyl.