| 摘要 |
Disclosed are heterocyclically condensed tetracycline compounds as represented by general formula (I), wherein Ring A is a pyrrolidine, piperidine or 1,4-diazepine moiety; wherein X is selected from halo, -R, -OR, -SR, -S(O)mR, -N(R)2, -N(R)C(O)R, N(R)C(O)OR’, and N(R)S(O)mR’; each R is independently selected from H, alkyl, carbocyclyl, or heterocyclyl; or two R groups taken together with the atom or atoms to which they are bound form a 4-7 membered non-aromatic heterocyclyl; and R’ is alkyl, carbocyclyl, or heterocyclyl; and wherein the remaining substituents are as defined herein. Further disclosed is a pharmaceutical composition which comprises a pharmaceutically acceptable carrier or diluent and a compound as defined above, for treating or preventing an infection or colonization in a subject. |
