| 摘要 |
<p>Provided are: a novel compound which binds to FKBP12 or a pharmaceutically acceptable salt thereof; and a novel therapeutic agent which contains the compound or a pharmaceutically acceptable salt thereof and is useful for the prophylaxis or treatment of alopecia. Specifically provided is a compound which is represented by formula (1) or a pharmaceutically acceptable salt thereof. (In formula (1), R represents a group represented by formula (2) or formula (3).) Compounds of the invention include: (S)-1-(2-(5-((3,4-dimethoxyphenoxy)methyl)-1,3,4-thiadiazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone, (S)-1-(2-(5-((3,4-dimethoxyphenoxy)methyl)-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone, (S)-1-(2-(5-((3,4-dimethoxyphenoxy)methyl)oxazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone, (S)-1-(2-(5-((3,4-dimethoxyphenoxy)methyl)thiazol-2-yl)pyrrolidin-1-yl)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone, and (S)-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)-1-(2-(5 -((pyrimidin-5-yloxy)methyl)isoxazol-3-yl)pyrrolidin-1-yl)ethanone.</p> |
