发明名称 |
SUBSTITUTED PYRIDINONE COMPOUNDS AS MEK INHIBITORS |
摘要 |
The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans. |
申请公布号 |
WO2014204263(A1) |
申请公布日期 |
2014.12.24 |
申请号 |
WO2014KR05464 |
申请日期 |
2014.06.20 |
申请人 |
THE ASAN FOUNDATION |
发明人 |
LEE, GIL NAM;JEON, HYE SUN;JEON, KI JOON;RHIM, CHUL YUN;KIM, JIN SUNG;SEO, JEONG BEOB;CHO, SUK YOUNG;KIM, CHOUNG SOO;LEE, JUNG SHIN;CHOI, EUN KYUNG;HWANG, JUNG JIN;KIM, BONG CHEOL |
分类号 |
A61K31/4745;A61K31/4245;A61K31/443;A61P35/00 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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