| 摘要 |
Disclosed is a dermal filler composition comprising: a) a hyaluronan polymer, consisting essentially of uncrosslinked hyaluronic acid having a mean molecular weight of at least about 2500000 Da, the uncrosslinked hyaluronan polymer being at least 95% by weight of the total hyaluronan polymer present in the composition; and b) mannitol present at about 0.5% (w/v) to about 5% (w/v) of the composition; wherein the composition has a dynamic viscosity of about 50 Pa•s to about 150 Pa•s (500P - 1500P). Also disclosed is an injectable dermal filler composition for rehydrating skin, the composition comprising; a) a hyaluronan polymer consisting essentially of hyaluronic acid having a mean molecular weight of at least 2,500,000 Da, wherein the hyaluronan polymer is present at a concentration of about 11.5 mg/mL to about 15.5 mg/mL, and wherein the composition is essentially free of crosslinked hyaluronan polymer; and b) mannitol present at about 0.5% (w/v) to about 5% (w/v) of the composition. Further disclosed is a method of making a dermal filler composition, the method comprising the steps of: a) combining mannitol with a physiologically-acceptable buffer to make a mannitol-buffered solution, wherein the mannitol is present at about 0.5% (w/v) to about 5% (w/v) of the solution; b) combining a hyaluronan polymer consisting essentially of uncrosslinked hyaluronic acid having a mean molecular weight of at least 2,500,000 Da, the uncross-linked hyaluronan polymer being at least 95% by weight of the total hyaluronan polymer, with the mannitol-buffered solution to hydrate the hyaluronan polymer, wherein the hyaluronan polymer is present at a concentration of about 11.5 mg/mL to about 15.5 mg/mL, and; c) sizing the fluid composition by recirculating the dermal filler composition between a first vessel and a second vessel through a narrow aperture; wherein the dermal filler composition has a dynamic viscosity of about 50 Pa•s to about 150 Pa•s. |
