发明名称 |
MONITORING AND ASSESSING DEACETYLASE ENZYME ACTIVITY |
摘要 |
Disclosed herein are compounds and methods for detecting enzyme activity. In some embodiments, the enzyme is a deacetylase enzyme such as HDAC. The compound of the invention comprises a detectable label, a linker, and an enamide group. The compound can be enzymatically cleaved by the enzyme of interest to produce a nucleophilic fragment that includs the detectable label. Measurement of a signal generated by the detectable label can indicate enzyme activity. The compounds can be used as either in vivo or in vitro enzyme probes. |
申请公布号 |
WO2014204917(A1) |
申请公布日期 |
2014.12.24 |
申请号 |
WO2014US42667 |
申请日期 |
2014.06.17 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
HOOKER, JACOB;DIYABALANGE, HIMASHINIE |
分类号 |
C12Q1/34 |
主分类号 |
C12Q1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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